4XBY

Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide

Summary for 4XBY

• Entry DOI: 10.2210/pdb4xby/pdb
• Related: 4xbt 4xbx
• Descriptor: Limonene-1,2-epoxide hydrolase, (1R,5S)-6-oxabicyclo[3.1.0]hexane (3 entities in total)
• Functional Keywords: epoxide hydrolase, hydrolase
• Biological source: Rhodococcus erythropolis
• Total number of polymer chains: 8
• Total formula weight: 139291.51

Authors

Kong, X.D.,Sun, Z.,Xu, J.H.,Reetz, M.T.,Zhou, J. (deposition date: 2014-12-17, release date: 2015-07-15, Last modification date: 2023-11-08)

• Primary citation: Sun, Z.,Lonsdale, R.,Kong, X.D.,Xu, J.H.,Zhou, J.,Reetz, M.T.; Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution; Angew.Chem.Int.Ed.Engl., 54:12410-12415, 2015; PubMed: 25891639; DOI: 10.1002/anie.201501809

Experimental method

X-RAY DIFFRACTION (2.3 Å)