4X80

Crystal Structure of murine 7B4 Fab monoclonal antibody against ADAMTS5

Summary for 4X80

• Entry DOI: 10.2210/pdb4x80/pdb
• Related: 4X8J
• Descriptor: IgG1 7B4 FAB Light Chain, IgG1 7B4 FAB Heavy chain (3 entities in total)
• Functional Keywords: monoclonal, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 2
• Total formula weight: 47693.81

Authors

Larkin, J.,Lohr, T.A.,Elefante, L.,Shearin, J.,Matico, R.,Su, J.-L.,Xue, Y.,Liu, F.,Genell, C.,Miller, R.E.,Tran, P.B.,Malfait, A.-M.,Maier, C.C.,Matheny, C.J. (deposition date: 2014-12-09, release date: 2015-04-08, Last modification date: 2024-11-06)

Primary citation

Larkin, J.,Lohr, T.A.,Elefante, L.,Shearin, J.,Matico, R.,Su, J.L.,Xue, Y.,Liu, F.,Genell, C.,Miller, R.E.,Tran, P.B.,Malfait, A.M.,Maier, C.C.,Matheny, C.J.
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Osteoarthr. Cartil., 23:1254-1266, 2015

PubMed Abstract: Aggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro, ex vivo and in vivo systems were utilized to assess target engagement, aggrecanase inhibition and modulation of disease-related endpoints with the intent of selecting a candidate for clinical development in osteoarthritis (OA).

PubMed: 25800415
DOI: 10.1016/j.joca.2015.02.778

Experimental method

X-RAY DIFFRACTION (2.6 Å)