4X6S

Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide

4X6S の概要

• エントリーDOI: 10.2210/pdb4x6s/pdb
• 分子名称: Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 (3 entities in total)
• 機能のキーワード: src homology domain, inhibitor, phosphotyrosine binding pocket, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm: Q14451
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 28080.05

構造登録者

Watson, G.M.,Panjikar, S.,Wilce, M.C.,Wilce, J.A. (登録日: 2014-12-09, 公開日: 2015-09-23, 最終更新日: 2015-10-28)

• 主引用文献: Watson, G.M.,Gunzburg, M.J.,Ambaye, N.D.,Lucas, W.A.,Traore, D.A.,Kulkarni, K.,Cergol, K.M.,Payne, R.J.,Panjikar, S.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A.; Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.; J.Med.Chem., 58:7707-7718, 2015; PubMed: 26359549; DOI: 10.1021/acs.jmedchem.5b00609

実験手法

X-RAY DIFFRACTION (2.55 Å)