4X6P

FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide

4X6P の概要

• エントリーDOI: 10.2210/pdb4x6p/pdb
• 関連するPDBエントリー: 4X6M 4X6N 4X6O
• 分子名称: Coagulation factor XI, light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide, ... (6 entities in total)
• 機能のキーワード: serine protease, blood coagulation factor, protein inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56002.10

構造登録者

Sheriff, S. (登録日: 2014-12-08, 公開日: 2015-02-18, 最終更新日: 2023-09-27)

• 主引用文献: Pinto, D.J.,Smallheer, J.M.,Corte, J.R.,Austin, E.J.,Wang, C.,Fang, T.,Smith, L.M.,Rossi, K.A.,Rendina, A.R.,Bozarth, J.M.,Zhang, G.,Wei, A.,Ramamurthy, V.,Sheriff, S.,Myers, J.E.,Morin, P.E.,Luettgen, J.M.,Seiffert, D.A.,Quan, M.L.,Wexler, R.R.; Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.; Bioorg.Med.Chem.Lett., 25:1635-1642, 2015; PubMed: 25728130; DOI: 10.1016/j.bmcl.2015.01.028

実験手法

X-RAY DIFFRACTION (1.93 Å)