4X6H
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Summary for 4X6H
Entry DOI | 10.2210/pdb4x6h/pdb |
Descriptor | Cathepsin K, 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide, ... (5 entities in total) |
Functional Keywords | cathepsin k, inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24738.57 |
Authors | Borisek, J.,Mohar, B.,Vizovisek, M.,Sosnowski, P.,Turk, D.,Turk, B.,Novic, M. (deposition date: 2014-12-08, release date: 2015-09-23, Last modification date: 2024-01-10) |
Primary citation | Borisek, J.,Vizovisek, M.,Sosnowski, P.,Turk, B.,Turk, D.,Mohar, B.,Novic, M. Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58:6928-6937, 2015 Cited by PubMed: 26280490DOI: 10.1021/acs.jmedchem.5b00746 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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