4X63
Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH
Summary for 4X63
Entry DOI | 10.2210/pdb4x63/pdb |
Related | 4X60 4X61 |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
Functional Keywords | protein-inhibitor complex, protein arginine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: O14744 Nucleus: Q9BQA1 |
Total number of polymer chains | 2 |
Total formula weight | 112393.89 |
Authors | Boriack-Sjodin, P.A. (deposition date: 2014-12-06, release date: 2015-04-22, Last modification date: 2015-05-27) |
Primary citation | Chan-Penebre, E.,Kuplast, K.G.,Majer, C.R.,Boriack-Sjodin, P.A.,Wigle, T.J.,Johnston, L.D.,Rioux, N.,Munchhof, M.J.,Jin, L.,Jacques, S.L.,West, K.A.,Lingaraj, T.,Stickland, K.,Ribich, S.A.,Raimondi, A.,Scott, M.P.,Waters, N.J.,Pollock, R.M.,Smith, J.J.,Barbash, O.,Pappalardi, M.,Ho, T.F.,Nurse, K.,Oza, K.P.,Gallagher, K.T.,Kruger, R.,Moyer, M.P.,Copeland, R.A.,Chesworth, R.,Duncan, K.W. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11:432-437, 2015 Cited by PubMed: 25915199DOI: 10.1038/nchembio.1810 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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