4X5Y

Menin in complex with MI-503

Summary for 4X5Y

Entry DOI	10.2210/pdb4x5y/pdb
Descriptor	Menin, 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ... (8 entities in total)
Functional Keywords	protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	56152.04
Authors	Pollock, J.,Borkin, D.,Cierpicki, T.,Grembecka, J. (deposition date: 2014-12-06, release date: 2015-04-15, Last modification date: 2023-12-27)
Primary citation	Borkin, D.,He, S.,Miao, H.,Kempinska, K.,Pollock, J.,Chase, J.,Purohit, T.,Malik, B.,Zhao, T.,Wang, J.,Wen, B.,Zong, H.,Jones, M.,Danet-Desnoyers, G.,Guzman, M.L.,Talpaz, M.,Bixby, D.L.,Sun, D.,Hess, J.L.,Muntean, A.G.,Maillard, I.,Cierpicki, T.,Grembecka, J. Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo. Cancer Cell, 27:589-602, 2015 Cited by PubMed: 25817203 DOI: 10.1016/j.ccell.2015.02.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation