4X4M

Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high affinity IgG binding

Summary for 4X4M

• Entry DOI: 10.2210/pdb4x4m/pdb
• Descriptor: Ig gamma-1 chain C region, High affinity immunoglobulin gamma Fc receptor I, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 167346.95

Authors

Lu, J.,Sun, P.D. (deposition date: 2014-12-03, release date: 2015-04-08, Last modification date: 2020-07-29)

• Primary citation: Lu, J.,Chu, J.,Zou, Z.,Hamacher, N.B.,Rixon, M.W.,Sun, P.D.; Structure of Fc gamma RI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding.; Proc.Natl.Acad.Sci.USA, 112:833-838, 2015; PubMed: 25561553; DOI: 10.1073/pnas.1418812112

Experimental method

X-RAY DIFFRACTION (3.485 Å)