4X4A

Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with 2,7-Anhydro-Neu5Ac

Summary for 4X4A

Entry DOI	10.2210/pdb4x4a/pdb
Descriptor	Anhydrosialidase, 2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC ACID, GLYCEROL, ... (6 entities in total)
Functional Keywords	intramolecular, trans-sialidase, sialidase, neuraminidase, 2-7-anhydro-neu5ac, reaction product, hydrolase, anhydrosialdiase
Biological source	Ruminococcus gnavus ATCC 29149
Total number of polymer chains	1
Total formula weight	54699.17
Authors	Owen, C.D.,Tailford, L.E.,Taylor, G.L.,Juge, N. (deposition date: 2014-12-02, release date: 2015-07-22, Last modification date: 2024-05-08)
Primary citation	Tailford, L.E.,Owen, C.D.,Walshaw, J.,Crost, E.H.,Hardy-Goddard, J.,Le Gall, G.,de Vos, W.M.,Taylor, G.L.,Juge, N. Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat Commun, 6:7624-7624, 2015 Cited by PubMed: 26154892 DOI: 10.1038/ncomms8624 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation