4X2T
X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M17 Leucyl Aminopeptidase from P. falciparum
Summary for 4X2T
Entry DOI | 10.2210/pdb4x2t/pdb |
Related | 3KQX 3KQZ 3KR4 4X2U |
Descriptor | M17 leucyl aminopeptidase, ZINC ION, (2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid, ... (7 entities in total) |
Functional Keywords | m17 leucyl-aminopeptidase, protease, inhibitor, tosedostat, antimalarial, plasmodium falciparum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 12 |
Total formula weight | 700419.22 |
Authors | Drinkwater, N.,McGowan, S. (deposition date: 2014-11-27, release date: 2015-02-18, Last modification date: 2023-09-27) |
Primary citation | Drinkwater, N.,Bamert, R.S.,Sivaraman, K.K.,Paiardini, A.,McGowan, S. X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17. Proteins, 83:789-795, 2015 Cited by PubMed: 25645579DOI: 10.1002/prot.24771 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.729 Å) |
Structure validation
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