4X2G

Selection of fragments for kinase inhibitor design: decoration is key

Summary for 4X2G

• Entry DOI: 10.2210/pdb4x2g/pdb
• Related: 4X2F
• Descriptor: TGF-beta receptor type-1, 4-[(4-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one, SULFATE ION, ... (5 entities in total)
• Functional Keywords: transferase, protein kinase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P36897
• Total number of polymer chains: 1
• Total formula weight: 35353.61

Authors

Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-26, release date: 2015-08-12, Last modification date: 2024-02-28)

• Primary citation: Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D.; Selection of fragments for kinase inhibitor design: decoration is key.; J.Med.Chem., 58:457-465, 2015; PubMed: 25437144; DOI: 10.1021/jm501597j

Experimental method

X-RAY DIFFRACTION (1.51 Å)