4X1B

Human serum transferrin with ferric ion bound at the C-lobe only

4X1B の概要

• エントリーDOI: 10.2210/pdb4x1b/pdb
• 関連するPDBエントリー: 4X1D
• 分子名称: Serotransferrin, FE (III) ION, MALONATE ION, ... (5 entities in total)
• 機能のキーワード: transferrin, ytterbium, ferric, malonate, metal transport
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P02787
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75534.46

構造登録者

Wang, M.,Zhang, H.,Sun, H. (登録日: 2014-11-24, 公開日: 2015-04-08, 最終更新日: 2024-10-23)

主引用文献

Wang, M.,Lai, T.P.,Wang, L.,Zhang, H.,Yang, N.,Sadler, P.J.,Sun, H.
"Anion clamp" allows flexible protein to impose coordination geometry on metal ions
Chem.Commun.(Camb.), 51:7867-7870, 2015

PubMed Abstract: X-ray crystal structures of human serum transferrin (77 kDa) with Yb(III) or Fe(III) bound to the C-lobe and malonate as the synergistic anion show that the large Yb(III) ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.

PubMed: 25854324
DOI: 10.1039/c4cc09642h

実験手法

X-RAY DIFFRACTION (2.45 Å)