4X0W

The crystal structure of mupain-1-17 in complex with murinised human uPA

Summary for 4X0W

• Entry DOI: 10.2210/pdb4x0w/pdb
• Related: 4N1P 4N1Q 4N1R 4N1S 4X1N
• Descriptor: mupain-1-17, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ... (5 entities in total)
• Functional Keywords: serine protease, peptidic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P00749
• Total number of polymer chains: 2
• Total formula weight: 29198.23

Authors

Jiang, L.,Zhao, B.,Xu, P.,Andreasen, P.,Huang, M. (deposition date: 2014-11-24, release date: 2015-10-21, Last modification date: 2017-10-18)

• Primary citation: Jiang, L.,Zhao, B.,Xu, P.,Srensen, H.P.,Jensen, J.K.,Christensen, A.,Hosseini, M.,Nielsen, N.C.,Jensen, K.J.,Andreasen, P.A.,Huang, M.; Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues.; Int.J.Biochem.Cell Biol., 62:88-92, 2015; PubMed: 25744057; DOI: 10.1016/j.biocel.2015.02.016

Experimental method

X-RAY DIFFRACTION (2.1 Å)