4X0W
The crystal structure of mupain-1-17 in complex with murinised human uPA
Summary for 4X0W
Entry DOI | 10.2210/pdb4x0w/pdb |
Related | 4N1P 4N1Q 4N1R 4N1S 4X1N |
Descriptor | mupain-1-17, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ... (5 entities in total) |
Functional Keywords | serine protease, peptidic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 2 |
Total formula weight | 29198.23 |
Authors | Jiang, L.,Zhao, B.,Xu, P.,Andreasen, P.,Huang, M. (deposition date: 2014-11-24, release date: 2015-10-21, Last modification date: 2017-10-18) |
Primary citation | Jiang, L.,Zhao, B.,Xu, P.,Srensen, H.P.,Jensen, J.K.,Christensen, A.,Hosseini, M.,Nielsen, N.C.,Jensen, K.J.,Andreasen, P.A.,Huang, M. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int.J.Biochem.Cell Biol., 62:88-92, 2015 Cited by PubMed: 25744057DOI: 10.1016/j.biocel.2015.02.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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