4WXR

X-ray crystal structure of NS3 Helicase from HCV with a bound inhibitor at 2.42 A resolution

Summary for 4WXR

• Entry DOI: 10.2210/pdb4wxr/pdb
• Related: 4WXP
• Descriptor: NS3, {6-(3,5-diaminophenyl)-1-[4-(propan-2-yl)benzyl]-1H-indol-3-yl}acetic acid (3 entities in total)
• Functional Keywords: helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus
• Total number of polymer chains: 2
• Total formula weight: 97428.61

Authors

Davies, D.R.,Kim, H.,Lorimer, D. (deposition date: 2014-11-14, release date: 2015-12-23, Last modification date: 2023-09-27)

• Primary citation: Buckman, B.O.,Kossen, K.,Misialek, S.,Stevens, S.,Rajagopalan, R.,Ruhmund, D.,Hooi, L.,Snarskaya, N.,Serebryany, V.,Wang, G.,Stoycheva, A.,Nicholas, J.B.,Davies, D.R.,Brunton, S.,Montalbetti, C.,Weddell, D.,Goodwin, C.,Schonfeld, D.,Mather, O.,Cheng, R.,Blatt, L.,Beigelman, L.; crystal structure of NS3 Helicase from HCV with a bound inhibitor; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.42 Å)