4WWQ
Apo structure of the Grb7 SH2 domain
Summary for 4WWQ
Entry DOI | 10.2210/pdb4wwq/pdb |
Descriptor | Growth factor receptor-bound protein 7, MALONIC ACID (3 entities in total) |
Functional Keywords | src homology domain, phosphotyrosine binding pocket, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q14451 |
Total number of polymer chains | 2 |
Total formula weight | 27485.48 |
Authors | Watson, G.M.,Ambaye, N.D.,Wilce, M.C.,Wilce, J.A. (deposition date: 2014-11-12, release date: 2015-09-23, Last modification date: 2023-09-27) |
Primary citation | Watson, G.M.,Gunzburg, M.J.,Ambaye, N.D.,Lucas, W.A.,Traore, D.A.,Kulkarni, K.,Cergol, K.M.,Payne, R.J.,Panjikar, S.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A. Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58:7707-7718, 2015 Cited by PubMed: 26359549DOI: 10.1021/acs.jmedchem.5b00609 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report