4WWO

Crystal structure of human PI3K-gamma in complex with phenylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine

4WWO の概要

• エントリーDOI: 10.2210/pdb4wwo/pdb
• 関連するPDBエントリー: 4WWN 4WWP
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine, ... (4 entities in total)
• 機能のキーワード: kinase, phosphotransfer, pip2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110570.11

構造登録者

Whittington, D.A.,Tang, J.,Yakowec, P. (登録日: 2014-11-11, 公開日: 2014-12-17, 最終更新日: 2024-02-28)

• 主引用文献: Cushing, T.D.,Hao, X.,Shin, Y.,Andrews, K.,Brown, M.,Cardozo, M.,Chen, Y.,Duquette, J.,Fisher, B.,Gonzalez-Lopez de Turiso, F.,He, X.,Henne, K.R.,Hu, Y.L.,Hungate, R.,Johnson, M.G.,Kelly, R.C.,Lucas, B.,McCarter, J.D.,McGee, L.R.,Medina, J.C.,San Miguel, T.,Mohn, D.,Pattaropong, V.,Pettus, L.H.,Reichelt, A.,Rzasa, R.M.,Seganish, J.,Tasker, A.S.,Wahl, R.C.,Wannberg, S.,Whittington, D.A.,Whoriskey, J.,Yu, G.,Zalameda, L.,Zhang, D.,Metz, D.P.; Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease.; J.Med.Chem., 58:480-511, 2015; PubMed: 25469863; DOI: 10.1021/jm501624r

実験手法

X-RAY DIFFRACTION (2.3 Å)