4WW8

Crystal structure of human carbonic anhydrase isozyme XII with 4-Propylthiobenzenesulfonamide

Summary for 4WW8

Entry DOI	10.2210/pdb4ww8/pdb
Related	4WR7 4WUP 4WUQ 4WW6
Descriptor	Carbonic anhydrase 12, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: O43570
Total number of polymer chains	4
Total formula weight	121663.13
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2014-11-10, release date: 2015-07-01, Last modification date: 2024-01-10)
Primary citation	Zubriene, A.,Smirnoviene, J.,Smirnov, A.,Morkunaite, V.,Michailoviene, V.,Jachno, J.,Juozapaitiene, V.,Norvaisas, P.,Manakova, E.,Grazulis, S.,Matulis, D. Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry. Biophys.Chem., 205:51-65, 2015 Cited by PubMed: 26079542 DOI: 10.1016/j.bpc.2015.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation