4WTG
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH SOFOSBUVIR DIPHOSPHATE GS-607596, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
4WTG の概要
エントリーDOI | 10.2210/pdb4wtg/pdb |
分子名称 | RNA PRIMER TEMPLATE CAAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ... (6 entities in total) |
機能のキーワード | hcv, viral, ns5b, rdrp, resistance mutation, template, primer, primed initiation, delta8 beta hairpin loop deletion, transferase-rna complex, transferase/rna |
由来する生物種 | Hepatitis C virus JFH-1 詳細 |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q99IB8 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 69366.75 |
構造登録者 | |
主引用文献 | Appleby, T.C.,Perry, J.K.,Murakami, E.,Barauskas, O.,Feng, J.,Cho, A.,Fox, D.,Wetmore, D.R.,McGrath, M.E.,Ray, A.S.,Sofia, M.J.,Swaminathan, S.,Edwards, T.E. Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347:771-775, 2015 Cited by PubMed: 25678663DOI: 10.1126/science.1259210 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
構造検証レポート
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