4WT6

Crystal structure of human Pim-1 kinase in complex with a thiadiazolamine-indole inhibitor.

Summary for 4WT6

Entry DOI	10.2210/pdb4wt6/pdb
Related	4WSY
Descriptor	Serine/threonine-protein kinase pim-1, 6-[5-(5-amino-1,3,4-thiadiazol-2-yl)-1H-indol-3-yl]-N-cyclopentylpyridin-2-amine, GLYCEROL, ... (4 entities in total)
Functional Keywords	transferase, serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	33532.99
Authors	Mohr, C. (deposition date: 2014-10-29, release date: 2015-02-11, Last modification date: 2023-12-27)
Primary citation	Wu, B.,Wang, H.L.,Cee, V.J.,Lanman, B.A.,Nixey, T.,Pettus, L.,Reed, A.B.,Wurz, R.P.,Guerrero, N.,Sastri, C.,Winston, J.,Lipford, J.R.,Lee, M.R.,Mohr, C.,Andrews, K.L.,Tasker, A.S. Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorg.Med.Chem.Lett., 25:775-780, 2015 Cited by PubMed: 25616902 DOI: 10.1016/j.bmcl.2014.12.091 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation