4WT2

Co-crystal Structure of MDM2 in Complex with AM-7209

4WT2 の概要

• エントリーDOI: 10.2210/pdb4wt2/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12984.90

構造登録者

Shaffer, P.L.,Huang, X.,Yakowec, P.,Long, A.M. (登録日: 2014-10-30, 公開日: 2014-12-03, 最終更新日: 2023-09-27)

• 主引用文献: Rew, Y.,Sun, D.,Yan, X.,Beck, H.P.,Canon, J.,Chen, A.,Duquette, J.,Eksterowicz, J.,Fox, B.M.,Fu, J.,Gonzalez, A.Z.,Houze, J.,Huang, X.,Jiang, M.,Jin, L.,Li, Y.,Li, Z.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,Oliner, J.D.,Osgood, T.,Saiki, A.Y.,Shaffer, P.,Wang, Y.C.,Wortman, S.,Yakowec, P.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H.; Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.; J.Med.Chem., 57:10499-10511, 2014; PubMed: 25384157; DOI: 10.1021/jm501550p

実験手法

X-RAY DIFFRACTION (1.42 Å)