4WSS

The crystal structure of hemagglutinin form A/chicken/New York/14677-13/1998 in complex with LSTa

4WSS の概要

• エントリーDOI: 10.2210/pdb4wss/pdb
• 関連するPDBエントリー: 4WSR 4WST 4WSU 4WSV 4WSW 4WSX
• 関連するBIRD辞書のPRD_ID: PRD_900067
• 分子名称: Hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: influenza virus, hemagglutinin, h6, viral protein
• 由来する生物種: Influenza A virus (A/chicken/New York/14677-13/1998(H6N2))
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 351663.80

構造登録者

Yang, H.,Carney, P.J.,Chang, J.C.,Villanueva, J.M.,Stevens, J. (登録日: 2014-10-28, 公開日: 2015-02-25, 最終更新日: 2024-10-09)

主引用文献

Yang, H.,Carney, P.J.,Chang, J.C.,Villanueva, J.M.,Stevens, J.
Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes.
J.Virol., 89:4612-4623, 2015

PubMed Abstract: During 2013, three new avian influenza A virus subtypes, A(H7N9), A(H6N1), and A(H10N8), resulted in human infections. While the A(H7N9) virus resulted in a significant epidemic in China across 19 provinces and municipalities, both A(H6N1) and A(H10N8) viruses resulted in only a few human infections. This study focuses on the major surface glycoprotein hemagglutinins from both of these novel human viruses. The detailed structural and glycan microarray analyses presented here highlight the idea that both A(H6N1) and A(H10N8) virus hemagglutinins retain a strong avian receptor binding preference and thus currently pose a low risk for sustained human infections.

PubMed: 25673707
DOI: 10.1128/JVI.03456-14

実験手法

X-RAY DIFFRACTION (2.8 Å)