4WRB

Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190)

4WRB の概要

• エントリーDOI: 10.2210/pdb4wrb/pdb
• 関連するPDBエントリー: 4WR8
• 分子名称: Macrophage migration inhibitory factor, 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: cd74 binding, tautomerase, inhibitor, complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 38704.78

構造登録者

Robertson, M.J.,Baxter, R.H.G.,Jorgensen, W.L. (登録日: 2014-10-23, 公開日: 2015-03-11, 最終更新日: 2023-12-27)

• 主引用文献: Dziedzic, P.,Cisneros, J.A.,Robertson, M.J.,Hare, A.A.,Danford, N.E.,Baxter, R.H.,Jorgensen, W.L.; Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.; J.Am.Chem.Soc., 137:2996-3003, 2015; PubMed: 25697265; DOI: 10.1021/ja512112j

実験手法

X-RAY DIFFRACTION (1.81 Å)