4WOT

ROCK2 IN COMPLEX WITH 1426382-07-1

4WOT の概要

• エントリーDOI: 10.2210/pdb4wot/pdb
• 分子名称: Rho-associated protein kinase 2, methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: O75116
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 183952.89

構造登録者

Augustin, M.,Krapp, S.,Boland, S.,Defert, O.,Bourin, A.,Alen, J.,Leysen, D. (登録日: 2014-10-16, 公開日: 2015-05-06, 最終更新日: 2024-05-08)

• 主引用文献: Boland, S.,Bourin, A.,Alen, J.,Geraets, J.,Schroeders, P.,Castermans, K.,Kindt, N.,Boumans, N.,Panitti, L.,Fransen, S.,Vanormelingen, J.,Stassen, J.M.,Leysen, D.,Defert, O.; Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.; J. Med. Chem., 58:4309-4324, 2015; PubMed: 25898023; DOI: 10.1021/acs.jmedchem.5b00308

実験手法

X-RAY DIFFRACTION (2.93 Å)