4WO0

Crystal structure of transthyretin in complex with apigenin

Summary for 4WO0

• Entry DOI: 10.2210/pdb4wo0/pdb
• Related: 4WNJ 4WNS
• Descriptor: Transthyretin, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (3 entities in total)
• Functional Keywords: transport protein, amyloidosis, negative cooperativity
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28095.19

Authors

Zanotti, G.,Cianci, M.,Folli, C.,Berni, R. (deposition date: 2014-10-15, release date: 2015-08-05, Last modification date: 2024-01-10)

• Primary citation: Cianci, M.,Folli, C.,Zonta, F.,Florio, P.,Berni, R.,Zanotti, G.; Structural evidence for asymmetric ligand binding to transthyretin.; Acta Crystallogr.,Sect.D, 71:1582-1592, 2015; PubMed: 26249340; DOI: 10.1107/S1399004715010585

Experimental method

X-RAY DIFFRACTION (1.339 Å)