4WNM
SYK catalytic domain in complex with a potent triazolopyridine inhibitor
Summary for 4WNM
Entry DOI | 10.2210/pdb4wnm/pdb |
Descriptor | Tyrosine-protein kinase SYK, N~3~-(tetrahydro-2H-pyran-4-yl)-N~6~-[5-(tetrahydro-2H-pyran-4-ylmethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indazole-3,6-diamine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | syk catalytic domain in complex with a potent triazolopyridine based inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 35424.57 |
Authors | Jackson, P.J. (deposition date: 2014-10-13, release date: 2016-01-20, Last modification date: 2023-12-27) |
Primary citation | Ferguson, G.D.,Delgado, M.,Plantevin-Krenitsky, V.,Jensen-Pergakes, K.,Bates, R.J.,Torres, S.,Celeridad, M.,Brown, H.,Burnett, K.,Nadolny, L.,Tehrani, L.,Packard, G.,Pagarigan, B.,Haelewyn, J.,Nguyen, T.,Xu, L.,Tang, Y.,Hickman, M.,Baculi, F.,Pierce, S.,Miyazawa, K.,Jackson, P.,Chamberlain, P.,LeBrun, L.,Xie, W.,Bennett, B.,Blease, K. A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation. Plos One, 11:e0145705-e0145705, 2016 Cited by PubMed: 26756335DOI: 10.1371/journal.pone.0145705 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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