4WN5

Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol

4WN5 の概要

• エントリーDOI: 10.2210/pdb4wn5/pdb
• 分子名称: Hypoxia-inducible factor 3-alpha, SULFATE ION, MONOVACCENIN, ... (5 entities in total)
• 機能のキーワード: hif-3alpha, pas domain, monoacylglycerol, lipid, fatty acid, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27358.77

構造登録者

Fala, A.M.,Oliveira, J.F.,Dias, S.M.,Ambrosio, A.L. (登録日: 2014-10-10, 公開日: 2015-08-05, 最終更新日: 2023-09-27)

主引用文献

Fala, A.M.,Oliveira, J.F.,Adamoski, D.,Aricetti, J.A.,Dias, M.M.,Dias, M.V.B.,Sforca, M.L.,Lopes-de-Oliveira, P.S.,Rocco, S.A.,Caldana, C.,Dias, S.M.G.,Ambrosio, A.L.B.
Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha.
Sci Rep, 5:12698-12698, 2015

PubMed Abstract: Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia.

PubMed: 26237540
DOI: 10.1038/srep12698

実験手法

X-RAY DIFFRACTION (1.15 Å)