4WM8

Crystal Structure of Human Enterovirus D68

4WM8 の概要

• エントリーDOI: 10.2210/pdb4wm8/pdb
• 関連するPDBエントリー: 4WM7
• 分子名称: VP1, VP2, VP3, ... (6 entities in total)
• 機能のキーワード: enterovirus, capsid, beta jelly roll, virus
• 由来する生物種: Enterovirus D68; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95202.61

構造登録者

Liu, Y.,Sheng, J.,Fokine, A.,Meng, G.,Long, F.,Kuhn, R.J.,Rossmann, M.G. (登録日: 2014-10-08, 公開日: 2015-01-14, 最終更新日: 2023-12-27)

主引用文献

Liu, Y.,Sheng, J.,Fokine, A.,Meng, G.,Shin, W.H.,Long, F.,Kuhn, R.J.,Kihara, D.,Rossmann, M.G.
Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
Science, 347:71-74, 2015

PubMed Abstract: Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.

PubMed: 25554786
DOI: 10.1126/science.1261962

実験手法

X-RAY DIFFRACTION (2 Å)