4WKO
Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hydroxybutylthio-DADMe-Immucillin-A
Summary for 4WKO
| Entry DOI | 10.2210/pdb4wko/pdb |
| Related | 4FFS 4WKC 4WKN 4WKP |
| Descriptor | Aminodeoxyfutalosine nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(4-hydroxybutyl)sulfanyl]methyl}pyrrolidin-3-ol (3 entities in total) |
| Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Helicobacter pylori |
| Total number of polymer chains | 1 |
| Total formula weight | 27238.34 |
| Authors | Cameron, S.A.,Wang, S.,Almo, S.C.,Schramm, V.L. (deposition date: 2014-10-02, release date: 2015-11-25, Last modification date: 2023-09-27) |
| Primary citation | Wang, S.,Cameron, S.A.,Clinch, K.,Evans, G.B.,Wu, Z.,Schramm, V.L.,Tyler, P.C. New Antibiotic Candidates against Helicobacter pylori. J.Am.Chem.Soc., 137:14275-14280, 2015 Cited by PubMed: 26494017DOI: 10.1021/jacs.5b06110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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