4WKI

Crystal structure of human ADAMTS-4 in complex with inhibitor 5-CHLORO-N-{[(4S)-4-(1-METHYL-1H-IMIDAZOL-2-YL)-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}-1-BENZOFURAN-2-CARBOXAMIDE (compound 11)

4WKI の概要

• エントリーDOI: 10.2210/pdb4wki/pdb
• 関連するPDBエントリー: 4WK7 4WKE
• 分子名称: A disintegrin and metalloproteinase with thrombospondin motifs 4, ZINC ION, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: metalloprotease, osteoarthritis, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : O75173
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26120.37

構造登録者

Durbin, J.D. (登録日: 2014-10-02, 公開日: 2014-12-10, 最終更新日: 2023-12-27)

• 主引用文献: Durham, T.B.,Klimkowski, V.J.,Rito, C.J.,Marimuthu, J.,Toth, J.L.,Liu, C.,Durbin, J.D.,Stout, S.L.,Adams, L.,Swearingen, C.,Lin, C.,Chambers, M.G.,Thirunavukkarasu, K.,Wiley, M.R.; Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.; J.Med.Chem., 57:10476-10485, 2014; PubMed: 25415648; DOI: 10.1021/jm501522n

実験手法

X-RAY DIFFRACTION (1.6 Å)