4WKF

Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution

Summary for 4WKF

Entry DOI	10.2210/pdb4wkf/pdb
Descriptor	Chitotriosidase-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	chit1, gh18 chitinase, protonation states, hydrolysis, catalytic mechanism, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42648.69
Authors	Fadel, F.,Zhao, Y.,Cachau, R.,Cousido-Siah, A.,Ruiz, F.X.,Harlos, K.,Howard, E.,Mitschler, A.,Podjarny, A. (deposition date: 2014-10-02, release date: 2015-07-08, Last modification date: 2020-07-29)
Primary citation	Fadel, F.,Zhao, Y.,Cachau, R.,Cousido-Siah, A.,Ruiz, F.X.,Harlos, K.,Howard, E.,Mitschler, A.,Podjarny, A. New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM. Acta Crystallogr.,Sect.D, 71:1455-1470, 2015 Cited by PubMed: 26143917 DOI: 10.1107/S139900471500783X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.101 Å)

Structure validation