4WKC

Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin-A

Summary for 4WKC

Entry DOI	10.2210/pdb4wkc/pdb
Related	1Y6Q 4WKN 4WKO 4WKP
Descriptor	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, TETRAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli O139:H28
Total number of polymer chains	1
Total formula weight	26588.40
Authors	Cameron, S.A.,Thomas, K.,Almo, S.C.,Schramm, V.L. (deposition date: 2014-10-02, release date: 2015-08-19, Last modification date: 2023-09-27)
Primary citation	Thomas, K.,Cameron, S.A.,Almo, S.C.,Burgos, E.S.,Gulab, S.A.,Schramm, V.L. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Biochemistry, 54:2520-2529, 2015 Cited by PubMed: 25806409 DOI: 10.1021/bi501487w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation