4WK9

Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (0.3mM) at 1.10 A resolution

4WK9 の概要

• エントリーDOI: 10.2210/pdb4wk9/pdb
• 分子名称: Chitotriosidase-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: chit1, gh18 chitinase, protonation states, hydrolysis, catalytic mechanism, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42648.69

構造登録者

Fadel, F.,Zhao, Y.,Cachau, R.,Cousido-Siah, A.,Ruiz, F.X.,Harlos, K.,Howard, E.,Mitschler, A.,Podjarny, A. (登録日: 2014-10-02, 公開日: 2015-07-08, 最終更新日: 2024-01-10)

• 主引用文献: Fadel, F.,Zhao, Y.,Cachau, R.,Cousido-Siah, A.,Ruiz, F.X.,Harlos, K.,Howard, E.,Mitschler, A.,Podjarny, A.; New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.; Acta Crystallogr.,Sect.D, 71:1455-1470, 2015; PubMed: 26143917; DOI: 10.1107/S139900471500783X

実験手法

X-RAY DIFFRACTION (1.102 Å)