4WJ5

Structure of HLA-A2 in complex with an altered peptide ligands based on Mart-1 variant epitope

4WJ5 の概要

• エントリーDOI: 10.2210/pdb4wj5/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (5 entities in total)
• 機能のキーワード: antigen presentation, major histocompatibility complex, hla-a2 antigen, altered peptide ligand, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769; Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 90634.70

構造登録者

Celie, P.H.N.,Rodenko, B.,Ovaa, H. (登録日: 2014-09-29, 公開日: 2014-10-29, 最終更新日: 2024-01-10)

• 主引用文献: Hoppes, R.,Oostvogels, R.,Luimstra, J.J.,Wals, K.,Toebes, M.,Bies, L.,Ekkebus, R.,Rijal, P.,Celie, P.H.,Huang, J.H.,Emmelot, M.E.,Spaapen, R.M.,Lokhorst, H.,Schumacher, T.N.,Mutis, T.,Rodenko, B.,Ovaa, H.; Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2-Restricted T Cell Epitopes.; J Immunol., 193:4803-4813, 2014; PubMed: 25311806; DOI: 10.4049/jimmunol.1400800

実験手法

X-RAY DIFFRACTION (1.65 Å)