4WIH

Crystal structure of cAMP-dependent Protein Kinase A from Cricetulus griseus

4WIH の概要

• エントリーDOI: 10.2210/pdb4wih/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP Dependent Protein Kinase Inhibitor PKI-tide (3 entities in total)
• 機能のキーワード: pka, kinase, serine/threonine-protein kinase, transferase, atp-binding, camp, nucleotide-binding
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• 細胞内の位置: Cytoplasm : P25321
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43107.08

構造登録者

Kudlinzki, D.,Linhard, V.L.,Saxena, K.,Dreyer, M.,Schwalbe, H. (登録日: 2014-09-25, 公開日: 2014-10-22, 最終更新日: 2024-11-06)

主引用文献

Kudlinzki, D.,Linhard, V.L.,Saxena, K.,Sreeramulu, S.,Gande, S.,Schieborr, U.,Dreyer, M.,Schwalbe, H.
High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.
Acta Crystallogr.,Sect.F, 71:1088-1093, 2015

PubMed Abstract: Protein kinases (PKs) are dynamic regulators of numerous cellular processes. Their phosphorylation activity is determined by the conserved kinase core structure, which is maintained by the interaction and dynamics with associated domains or interacting proteins. The prototype enzyme for investigations to understand the activity and regulation of PKs is the catalytic subunit of cAMP-dependent protein kinase (PKAc). Major effects of functional regulation and ligand binding are driven by only minor structural modulations in protein-protein interactions. In order to resolve such minor structural differences, very high resolution structures are required. Here, the high-resolution X-ray structure of PKAc from Cricetulus griseus is reported.

PubMed: 26249705
DOI: 10.1107/S2053230X1501242X

実験手法

X-RAY DIFFRACTION (1.139 Å)