4WHZ
Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
Summary for 4WHZ
Entry DOI | 10.2210/pdb4whz/pdb |
Descriptor | Mitogen-activated protein kinase 10, 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide (3 entities in total) |
Functional Keywords | jnk3, jnk2, jnk1, p38, kinase inhibitor, parkinson disease, isoform-selectivity, aminopyrazole, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P53779 |
Total number of polymer chains | 1 |
Total formula weight | 44590.87 |
Authors | Park, H.,LoGrasso, P. (deposition date: 2014-09-24, release date: 2014-11-26, Last modification date: 2023-12-27) |
Primary citation | Zheng, K.,Iqbal, S.,Hernandez, P.,Park, H.,LoGrasso, P.V.,Feng, Y. Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives. J.Med.Chem., 57:10013-10030, 2014 Cited by PubMed: 25393557DOI: 10.1021/jm501256y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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