4WHZ

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Summary for 4WHZ

Entry DOI	10.2210/pdb4whz/pdb
Descriptor	Mitogen-activated protein kinase 10, 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide (3 entities in total)
Functional Keywords	jnk3, jnk2, jnk1, p38, kinase inhibitor, parkinson disease, isoform-selectivity, aminopyrazole, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P53779
Total number of polymer chains	1
Total formula weight	44590.87
Authors	Park, H.,LoGrasso, P. (deposition date: 2014-09-24, release date: 2014-11-26, Last modification date: 2023-12-27)
Primary citation	Zheng, K.,Iqbal, S.,Hernandez, P.,Park, H.,LoGrasso, P.V.,Feng, Y. Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives. J.Med.Chem., 57:10013-10030, 2014 Cited by PubMed: 25393557 DOI: 10.1021/jm501256y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation