4WHZ

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

4WHZ の概要

• エントリーDOI: 10.2210/pdb4whz/pdb
• 分子名称: Mitogen-activated protein kinase 10, 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide (3 entities in total)
• 機能のキーワード: jnk3, jnk2, jnk1, p38, kinase inhibitor, parkinson disease, isoform-selectivity, aminopyrazole, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44590.87

構造登録者

Park, H.,LoGrasso, P. (登録日: 2014-09-24, 公開日: 2014-11-26, 最終更新日: 2023-12-27)

• 主引用文献: Zheng, K.,Iqbal, S.,Hernandez, P.,Park, H.,LoGrasso, P.V.,Feng, Y.; Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives.; J.Med.Chem., 57:10013-10030, 2014; PubMed: 25393557; DOI: 10.1021/jm501256y

実験手法

X-RAY DIFFRACTION (1.79 Å)