4WHY

Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P21 crystal form

4WHY の概要

• エントリーDOI: 10.2210/pdb4why/pdb
• 関連するPDBエントリー: 4WHT
• 分子名称: epitope peptide, Heavy chain of Fab fragment derived from neutralizing antibody 3/11, Light chain of Fab fragment derived from neutralizing antibody 3/11, ... (4 entities in total)
• 機能のキーワード: neutralizing epitope, envelope glycoprotein, e2, receptor-binding, viral protein
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 208747.34

構造登録者

Krey, T.,Rey, F.A. (登録日: 2014-09-24, 公開日: 2014-12-17, 最終更新日: 2015-02-04)

• 主引用文献: Meola, A.,Tarr, A.W.,England, P.,Meredith, L.W.,McClure, C.P.,Foung, S.K.,McKeating, J.A.,Ball, J.K.,Rey, F.A.,Krey, T.; Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein e2 recognized by broadly neutralizing antibodies.; J.Virol., 89:2170-2181, 2015; PubMed: 25473061; DOI: 10.1128/JVI.02190-14

実験手法

X-RAY DIFFRACTION (2.62 Å)