4WH6
Crystal structure of HCV NS3/4A protease variant R155K in complex with Asunaprevir
Summary for 4WH6
Entry DOI | 10.2210/pdb4wh6/pdb |
Related | 4WF8 |
Descriptor | Genome polyprotein, SULFATE ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | hcv drug resistant, protease-inhibitor complex, asunaprevir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus subtype 1a |
Total number of polymer chains | 1 |
Total formula weight | 22239.89 |
Authors | Soumana, D.I.,Ali, A.,Schiffer, C.A. (deposition date: 2014-09-20, release date: 2014-10-08, Last modification date: 2023-12-27) |
Primary citation | Soumana, D.I.,Ali, A.,Schiffer, C.A. Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease. Acs Chem.Biol., 9:2485-2490, 2014 Cited by PubMed: 25243902DOI: 10.1021/cb5006118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
Download full validation report