4WFV

Bovine allergen Bos d 2 in the monoclinic space group C2.

4WFV の概要

• エントリーDOI: 10.2210/pdb4wfv/pdb
• 関連するPDBエントリー: 1BJ7 4WFU
• 分子名称: Allergen Bos d 2 (2 entities in total)
• 機能のキーワード: allergen, lipocalin
• 由来する生物種: Bos taurus (Bovine)
• 細胞内の位置: Secreted: Q28133
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17867.98

構造登録者

Niemi, M.H.,Rouvinen, J. (登録日: 2014-09-17, 公開日: 2015-09-16, 最終更新日: 2024-11-20)

主引用文献

Niemi, M.H.,Rytkonen-Nissinen, M.,Miettinen, I.,Janis, J.,Virtanen, T.,Rouvinen, J.
Dimerization of lipocalin allergens.
Sci Rep, 5:13841-13841, 2015

PubMed Abstract: Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for bovine dander lipocalin Bos d 2, which was earlier described as a monomeric allergen. The crystal structure analysis of all other determined lipocalin allergens also revealed oligomeric structures which broadly utilize inherent structural features of the β-sheet in dimer formation. According to the moderate size of monomer-monomer interfaces, most of these dimers would be transient in solution. Native mass spectrometry was employed to characterize quantitatively transient dimerization of two lipocalin allergens, Bos d 2 and Bos d 5, in solution.

PubMed: 26346541
DOI: 10.1038/srep13841

実験手法

X-RAY DIFFRACTION (1.4 Å)