4WA4

The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals in complex with oseltamivir carboxylate

Summary for 4WA4

• Entry DOI: 10.2210/pdb4wa4/pdb
• Related: 4WA1 4WA2 4WA3 4WA5
• Descriptor: Neuraminidase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, ... (5 entities in total)
• Functional Keywords: neuraminidase, influenza virus, seal, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))
• Cellular location: Virion membrane : I6NW33
• Total number of polymer chains: 1
• Total formula weight: 43628.11

Authors

Yang, H.,Villanueva, J.M.,Gubareva, L.V.,Stevens, J. (deposition date: 2014-08-28, release date: 2015-01-14, Last modification date: 2023-12-27)

• Primary citation: Yang, H.,Nguyen, H.T.,Carney, P.J.,Guo, Z.,Chang, J.C.,Jones, J.,Davis, C.T.,Villanueva, J.M.,Gubareva, L.V.,Stevens, J.; Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals.; J.Virol., 89:2801-2812, 2015; PubMed: 25540377; DOI: 10.1128/JVI.02723-14

Experimental method

X-RAY DIFFRACTION (1.95 Å)