4W9Y

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47

4W9Y の概要

• エントリーDOI: 10.2210/pdb4w9y/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, glutamyl sulfamide, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 82732.82

構造登録者

Pavlicek, J.,Barinka, C. (登録日: 2014-08-28, 公開日: 2015-09-23, 最終更新日: 2024-01-31)

• 主引用文献: Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C.; Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors.; J.Chem.Inf.Model., 2024; PubMed: 38224368; DOI: 10.1021/acs.jcim.3c01542

実験手法

X-RAY DIFFRACTION (1.64 Å)