4W9W

Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762

4W9W の概要

• エントリーDOI: 10.2210/pdb4w9w/pdb
• 分子名称: BMP-2-inducible protein kinase, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, small-molecule, catalytic domain, protein binding, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q9NSY1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35391.75

構造登録者

Sorrell, F.J.,Elkins, J.M.,Krojer, T.,Savitsky, P.,Williams, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2014-08-28, 公開日: 2014-09-10, 最終更新日: 2024-05-08)

• 主引用文献: Sorrell, F.J.,Szklarz, M.,Abdul Azeez, K.R.,Elkins, J.M.,Knapp, S.; Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.; Structure, 24:401-411, 2016; PubMed: 26853940; DOI: 10.1016/j.str.2015.12.015

実験手法

X-RAY DIFFRACTION (1.72 Å)