4W9Q

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one

4W9Q の概要

• エントリーDOI: 10.2210/pdb4w9q/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one (3 entities in total)
• 機能のキーワード: fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, isomerase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q13451
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14597.59

構造登録者

Pomplun, S.,Wang, Y.,Kirschner, K.,Kozany, C.,Bracher, A.,Hausch, F. (登録日: 2014-08-27, 公開日: 2014-12-03, 最終更新日: 2024-01-10)

• 主引用文献: Pomplun, S.,Wang, Y.,Kirschner, A.,Kozany, C.,Bracher, A.,Hausch, F.; Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).; Angew.Chem.Int.Ed.Engl., 54:345-348, 2015; PubMed: 25412894; DOI: 10.1002/anie.201408776

実験手法

X-RAY DIFFRACTION (1.08 Å)