4W7T

Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990

Summary for 4W7T

Entry DOI	10.2210/pdb4w7t/pdb
Descriptor	Heat shock protein HSP 90-alpha, (7S)-2-amino-4-methyl-7-phenyl-7,8-dihydroquinazolin-5(6H)-one (3 entities in total)
Functional Keywords	atp-binding domain, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	26855.07
Authors	Bellamacina, C.R.,Shafer, C.M.,Bussiere, D. (deposition date: 2014-08-22, release date: 2014-11-26, Last modification date: 2024-04-03)
Primary citation	McBride, C.M.,Levine, B.,Xia, Y.,Bellamacina, C.,Machajewski, T.,Gao, Z.,Renhowe, P.,Antonios-McCrea, W.,Barsanti, P.,Brinner, K.,Costales, A.,Doughan, B.,Lin, X.,Louie, A.,McKenna, M.,Mendenhall, K.,Poon, D.,Rico, A.,Wang, M.,Williams, T.E.,Abrams, T.,Fong, S.,Hendrickson, T.,Lei, D.,Lin, J.,Menezes, D.,Pryer, N.,Taverna, P.,Xu, Y.,Zhou, Y.,Shafer, C.M. Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990. J.Med.Chem., 57:9124-9129, 2014 Cited by PubMed: 25368984 DOI: 10.1021/jm501107q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation