4W7P
Crystal Structure of ROCK 1 bound to YB-15-QD37
Summary for 4W7P
Entry DOI | 10.2210/pdb4w7p/pdb |
Descriptor | Rho-associated protein kinase 1, N~1~-[2-(1H-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine (3 entities in total) |
Functional Keywords | inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13464 |
Total number of polymer chains | 4 |
Total formula weight | 190839.59 |
Authors | Sprague, E.R. (deposition date: 2014-08-22, release date: 2014-10-15, Last modification date: 2023-12-27) |
Primary citation | Shaw, D.,Hollingworth, G.,Soldermann, N.,Sprague, E.,Schuler, W.,Vangrevelinghe, E.,Duggan, N.,Thomas, M.,Kosaka, T.,Waters, N.,van Eis, M.J. Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg.Med.Chem.Lett., 24:4812-4817, 2014 Cited by PubMed: 25248678DOI: 10.1016/j.bmcl.2014.09.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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