4W6E
Human Tankyrase 1 with small molecule inhibitor
Summary for 4W6E
Entry DOI | 10.2210/pdb4w6e/pdb |
Related | 4W5S |
Descriptor | Tankyrase-1, ZINC ION, 2-(4-{6-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one, ... (4 entities in total) |
Functional Keywords | tankyrase inhibitor small molecule, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 1 |
Total formula weight | 24748.47 |
Authors | Kazmirski, S.L.,Johannes, J.,Boriack-Sjodin, P.A.,Howard, T. (deposition date: 2014-08-20, release date: 2015-05-13, Last modification date: 2023-12-27) |
Primary citation | Johannes, J.W.,Almeida, L.,Barlaam, B.,Boriack-Sjodin, P.A.,Casella, R.,Croft, R.A.,Dishington, A.P.,Gingipalli, L.,Gu, C.,Hawkins, J.L.,Holmes, J.L.,Howard, T.,Huang, J.,Ioannidis, S.,Kazmirski, S.,Lamb, M.L.,McGuire, T.M.,Moore, J.E.,Ogg, D.,Patel, A.,Pike, K.G.,Pontz, T.,Robb, G.R.,Su, N.,Wang, H.,Wu, X.,Zhang, H.J.,Zhang, Y.,Zheng, X.,Wang, T. Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Acs Med.Chem.Lett., 6:254-259, 2015 Cited by PubMed: 25815142DOI: 10.1021/ml5003663 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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