4W5I

Crystal structure of human tankyrase 2 in complex with 1-methyl-7-phenyl-1,2,3,4,5,6-hexahydro-1,6- naphthyridin-5-one

Summary for 4W5I

Entry DOI	10.2210/pdb4w5i/pdb
Descriptor	Tankyrase-2, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywords	transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	2
Total formula weight	55687.29
Authors	Haikarainen, T.,Lehtio, L. (deposition date: 2014-08-18, release date: 2015-06-10, Last modification date: 2024-05-08)
Primary citation	Kumpan, K.,Nathubhai, A.,Zhang, C.,Wood, P.J.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Lehtio, L.,Threadgill, M.D. Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Bioorg.Med.Chem., 23:3013-3032, 2015 Cited by PubMed: 26026769 DOI: 10.1016/j.bmc.2015.05.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation