4W2F
Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites
This is a non-PDB format compatible entry.
Summary for 4W2F
Entry DOI | 10.2210/pdb4w2f/pdb |
Descriptor | 16S Ribosomal RNA, 30S Ribosomal Protein S10, 30S Ribosomal Protein S11, ... (61 entities in total) |
Functional Keywords | amicoumacin, antibiotic, 70s ribosome, inhibition of translation, translocation inhibitor, 30s subunit with amicoumacin, mrna, deacylated a-, p-, and e-site trnas of the 1st 70s ribosome in the asu, functional complex of bacterial 70s ribosome with antibiotic amicoumacin, ribosome-antibiotic complex, ribosome/antibiotic |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4558563.00 |
Authors | Polikanov, Y.S.,Osterman, I.A.,Szal, T.,Tashlitsky, V.N.,Serebryakova, M.V.,Kusochek, P.,Bulkley, D.,Malanicheva, I.A.,Efimenko, T.A.,Efremenkova, O.V.,Konevega, A.L.,Shaw, K.J.,Bogdanov, A.A.,Rodnina, M.V.,Dontsova, O.A.,Mankin, A.S.,Steitz, T.A.,Sergiev, P.V. (deposition date: 2014-09-12, release date: 2014-10-15, Last modification date: 2023-12-27) |
Primary citation | Polikanov, Y.S.,Osterman, I.A.,Szal, T.,Tashlitsky, V.N.,Serebryakova, M.V.,Kusochek, P.,Bulkley, D.,Malanicheva, I.A.,Efimenko, T.A.,Efremenkova, O.V.,Konevega, A.L.,Shaw, K.J.,Bogdanov, A.A.,Rodnina, M.V.,Dontsova, O.A.,Mankin, A.S.,Steitz, T.A.,Sergiev, P.V. Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56:531-540, 2014 Cited by PubMed: 25306919DOI: 10.1016/j.molcel.2014.09.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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