4V60

The structure of rat liver vault at 3.5 angstrom resolution

これはPDB形式変換不可エントリーです。

4V60 の概要

• エントリーDOI: 10.2210/pdb4v60/pdb
• 関連するPDBエントリー: 2ZV4 2ZV5
• 分子名称: Major vault protein (1 entity in total)
• 機能のキーワード: 9 repeat domains, protein-protein complex, ribonucleoprotein, structural protein
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cytoplasm: Q62667
• タンパク質・核酸の鎖数: 39
• 化学式量合計: 3740884.25

構造登録者

Kato, K.,Zhou, Y.,Tanaka, H.,Yao, M.,Yamashita, E.,Yoshimura, M.,Tsukihara, T. (登録日: 2008-10-24, 公開日: 2014-07-09, 最終更新日: 2024-04-03)

主引用文献

Tanaka, H.,Kato, K.,Yamashita, E.,Sumizawa, T.,Zhou, Y.,Yao, M.,Iwasaki, K.,Yoshimura, M.,Tsukihara, T.
The structure of rat liver vault at 3.5 angstrom resolution
Science, 323:384-388, 2009

PubMed Abstract: Vaults are among the largest cytoplasmic ribonucleoprotein particles and are found in numerous eukaryotic species. Roles in multidrug resistance and innate immunity have been suggested, but the cellular function remains unclear. We have determined the x-ray structure of rat liver vault at 3.5 angstrom resolution and show that the cage structure consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains. Each MVP monomer folds into 12 domains: nine structural repeat domains, a shoulder domain, a cap-helix domain, and a cap-ring domain. Interactions between the 42-turn-long cap-helix domains are key to stabilizing the particle. The shoulder domain is structurally similar to a core domain of stomatin, a lipid-raft component in erythrocytes and epithelial cells.

PubMed: 19150846
DOI: 10.1126/science.1164975

実験手法

X-RAY DIFFRACTION (3.5 Å)